KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
AURKA
All Species:
32.73
Human Site:
Y246
Identified Species:
48
UniProt:
O14965
Number Species:
15
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O14965
NP_003591.2
403
45809
Y246
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
Chimpanzee
Pan troglodytes
XP_525364
403
45791
Y246
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
Rhesus Macaque
Macaca mulatta
XP_001098364
471
52859
Y318
E
L
A
D
A
L
T
Y
C
H
E
K
K
V
I
Dog
Lupus familis
XP_853397
405
45606
Y247
E
L
A
D
A
L
S
Y
C
H
S
K
R
V
I
Cat
Felis silvestris
Mouse
Mus musculus
P97477
395
44754
Y237
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
Rat
Rattus norvegicus
P59241
397
44856
Y239
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001521399
303
34973
H153
C
H
S
K
K
V
I
H
R
D
I
K
P
E
N
Chicken
Gallus gallus
XP_425725
409
46456
A248
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
Frog
Xenopus laevis
Q91819
408
46443
Y253
Q
L
A
E
A
L
L
Y
C
H
S
K
K
V
I
Zebra Danio
Brachydanio rerio
Q6NW76
320
36928
K170
A
L
Q
Y
C
H
E
K
K
V
I
H
R
D
I
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VKN7
329
38282
D178
L
N
N
V
I
H
R
D
L
K
P
E
N
I
L
Honey Bee
Apis mellifera
XP_395732
327
37711
L177
I
S
Q
L
A
D
A
L
K
Y
C
H
S
K
K
Nematode Worm
Caenorhab. elegans
O01427
305
34731
K155
N
V
I
H
R
D
I
K
P
E
N
L
L
I
G
Sea Urchin
Strong. purpuratus
XP_001181990
278
32048
I128
Y
C
H
S
K
K
V
I
H
R
D
I
K
P
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q683C9
282
32738
Y132
S
L
A
R
A
L
I
Y
C
H
G
K
H
V
I
Baker's Yeast
Sacchar. cerevisiae
P38991
367
42927
Y217
Q
I
A
N
A
L
D
Y
M
H
K
K
N
I
I
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
100
47.7
89.8
N.A.
82.6
83.6
N.A.
65.5
73.1
65.9
53.3
N.A.
38.4
53
46.6
50.6
Protein Similarity:
100
100
62.2
93
N.A.
86.8
87.3
N.A.
70.2
82.8
77.2
65.7
N.A.
57.8
67
56.3
60
P-Site Identity:
100
100
73.3
93.3
N.A.
100
100
N.A.
6.6
0
73.3
20
N.A.
0
6.6
0
0
P-Site Similarity:
100
100
93.3
100
N.A.
100
100
N.A.
26.6
26.6
86.6
20
N.A.
20
20
26.6
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
46.4
38.9
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
55.3
57.5
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
66.6
53.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
66.6
73.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
0
57
0
63
0
7
7
0
0
0
0
0
0
7
% A
% Cys:
7
7
0
0
7
0
0
0
50
0
7
0
0
0
0
% C
% Asp:
0
0
7
13
0
13
7
7
0
7
7
0
0
7
0
% D
% Glu:
38
0
0
13
0
0
7
0
0
7
7
7
7
7
7
% E
% Phe:
0
7
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
7
0
0
0
7
% G
% His:
0
7
7
7
0
13
0
7
7
57
0
13
7
0
0
% H
% Ile:
7
7
7
0
7
0
19
7
0
0
19
7
0
19
63
% I
% Lys:
7
0
0
7
13
7
0
13
13
7
7
63
19
7
7
% K
% Leu:
7
57
0
7
0
57
7
7
7
0
0
7
7
7
7
% L
% Met:
0
0
0
0
0
0
0
0
7
0
0
0
0
0
0
% M
% Asn:
7
7
7
32
0
0
0
0
0
0
7
0
13
0
7
% N
% Pro:
0
0
0
0
0
0
0
0
7
0
7
0
7
7
0
% P
% Gln:
13
0
13
0
7
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
7
7
7
7
0
7
7
0
0
38
0
0
% R
% Ser:
7
7
7
7
0
0
32
0
0
0
38
0
7
0
0
% S
% Thr:
0
0
0
0
0
0
13
0
7
0
0
7
0
0
0
% T
% Val:
0
7
0
7
0
7
7
0
0
7
0
0
0
50
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
7
0
0
7
0
0
0
57
0
13
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _